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Dr Leto Kyritsi

Biologist - Bioinformatician

Leto Kyritsi studied Molecular Biology and Genetics, and obtained an M.Sc. in Biosystems and Informatics from the University of Liverpool.

In Liverpool she did protein expression research for the University's Department of Medicine (Oncology Research Unit and TheRyte Ltd.) where she initiated a project for modelling protein-protein interaction networks in normal vs. cancer cells as scale-free networks. She was a member of the Biocomputation and Computational Biology Group, led by Ray C. Paton, with whom she collaborated for the "Multidisciplinary Approaches to Theory in Medicine" book series (Elsevier Science).

She has a PhD from the Department of Chemistryof the Aristotle University of Thessaloniki. Her doctoral research was carried out under the supervision of Professors Theodora Choli-Papadopoulou and Anastasia Pantazaki (Dept. of Chemistry) and Stergios Logothetidis (Dept. of Physics). Her research entailed investigating the effect of ultradilute solutions on cells and tissues of various types, by means of biochemical and biophysical methodologies.

Her Doctoral Thesis (in Greek) updated with a theoretical supplement can be accessed here: [Thesis PDF]

Publications

  • Warenius H., Kyritsi L., Grierson I., Howarth A., Seabra L., Jones M., Thomas C., Browning P., White R. (2009). Spontaneous regression of human cancer cells in vitro: potential role of disruption of Cdk1/Cdk4 co-expression. Anticancer research 29(6):1933-41.
  • Warenius H., Seabra L., Kyritsi L., White R., Dormer R., Anandappa S., Thomas C., Howarth A. (2008). Theranostic proteomic profiling of cyclins, cyclin dependent kinases and ras in human cancer cell lines is dependent on p53 mutational status. Int J Oncol. 32(4):895-907.
  • Warenius H., Howarth A., Seabra L., Kyritsi L., Dormer R., Anandappa S., Thomas C. (2008). Dynamic heterogeneity of proteomic expression in human cancer cells does not affect Cdk1-Cdk4 co-expression. J Exp Ther Oncol. 7(3):237-54.
  • M.Sc. Thesis: "Analysis, design and implementation of a program to explore ecologies of biological information on the World Wide Web". The project entailed the construction of a tool for extensive interaction with the Web and automated textual data mining and analysis, and was implemented in Python.

Presentations

  • Kyritsi L., Logothetidis S., Choli-Papadopoulou Th. Biphasic effects of ultradilute chemotoxic agents on cell viability and genotoxicity. 14th International Conference on Nanosciences & Nanotechnologies (NN17). Thessaloniki 2017.
  • Kyritsi L., Choli-Papadopoulou Th. Biphasic response effects on cells from ultra-low doses of chemotoxic agents. 66th Conference of the Hellenic Society for Molecular Biology & Biochemistry. Athens 2016.
  • Warenius H., Kyritsi L. Neostasis as a therapeutically vulnerable homogeneous component of robust cancer systems. 6th International Conference on Pathways, Networks, and Systems Medicine. Crete 2008.
  • Warenius H., Seabra L., Kyritsi L., Jones M., Thomas C., White R., Browning P., Howarth A. Proteomic co-expression patterns of Critical Normal Genes are found in human cancer cell lines but not in normal cells. British Cancer Research Conference. Manchester 2004.

Talks

    • The response of biological systems to ultradilute potentised solutions.. At the 4th Transdisciplinary Conference on Medical Homeopathy and Medical Acupuncture, organised under the auspices of the Hellenic Medical Council (I.O.A.). Athens 2017.
    • Biphasic response effects on cells from ultra-low doses of chemotoxic agents. At the 17th Hellenic Congress on Homeopathic Medicine, Athens 2015.
    • Networks in biology. In the context of the conference on "Networks in Art & Life". AKTO School of Art, Athens 2015.
    • The biochemistry of the homeopathic idiosyncrasy (with Spiros Kivellos, MD). At the 16th Hellenic Congress on Homeopathic Medicine. Syros 2012.

    Contact: l.kyritsi (at) yahoo.com

     

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